Clinical effects of viral hepatitis in people living with HIV/AIDS in Anambra State, Nigeria
Keyword : HIV, HBV, HCV, CD4, risk factors
Author(s) : Nweke, R.N1., Oyeka, C.A2., Ikpeze, O.O3 And Nweke, B.U4
Abstract : ABSTRACT This study evaluated the patterns of cluster of differentiation T-lymphocytes class-4 (CD4) cells and their correlation with prevalence of HBV and HCV among HIV infected individuals between September 2015 and December 2016. Five hundred and two individuals living with Human Immunodeficiency Virus that participated in the study were randomly selected from those attending clinics at General Hospital Onitsha, General Hospital Ekwulobia and General Hospital Enugwu-Ukwu in Anambra State, Nigeria. The participants comprised of 346 (68.9%) females and 156 (31.1%) males. Veinous blood samples from the participants were used to perform HBsAg, anti-HCV serological tests and CD4 cells count. The sero-prevalence of HIV/HBV and HIV/HCV co-infections were 5.2% and 1.6% respectively. Higher percentage of male (9.6) were co-infected with HIV/HBV than females (3.2%) while higher percentage of females (2%) were co-infected with HIV/HCV than males (0.6%). Among the participants; 399 (79.5%) were on ART while 103 (20.5%) were Non-ART. Four hundred and ten participants (81.7%) had CD4 count 200cells/ l and above while 92 (18.3%) had CD4 count less than 200. The mean CD4 of the female participants was higher (546.8 18.8) than the males, (489.0±30.1). Also the mean CD4 of participants co-infected with HIV/HBV was lower (494.9±81.3) than those negative to HBV (531.0±16.3) while the mean CD4 of participants co-infected with HIV/HCV was higher (673..4±13.7) than those negative to HCV (526.8±16.1). Age, gender and exposure to risk factors significantly affected the co-infection of HIV/HBsAg but were not significant for co-infection of HIV/HCV. Keywords: HIV, HBV, HCV, CD4, risk factors